New Hope — and an Old Hurdle — for a Terrible Disease With Terrible Treatments
Three years ago, Jesús Tilano went to a hospital in a thickly forested valley in Colombia with large open lesions on his nose, right arm and left hand. He was diagnosed with leishmaniasis, a parasitic disease that is spread in the bite of a female sand fly and which plagues poor people who work in fields or forests across developing countries.He was prescribed a drug that required three injections a day for 20 days, each one agonizingly painful. Mr. Tilano, 85, had to make repeated expensive bus trips to town to get them. Then his kidneys started to fail, which is a common side effect of the drug, as are heart failure and liver damage.“The cure was worse than what I had before,” Mr. Tilano said.Leishmaniasis is a terrible disease, with terrible treatments that have hardly changed in a cent...